Kathy Bates, 76, displays her incredible 100Ib weight loss at CBS curtain-raiser after revealing the moment that sparked her Ozempic journey

The results of an undeniably effective weight loss journey were evident as Kathy Bates attended a CBS television event in Los Angeles on Wednesday evening. 

The celebrated actress has lost more than 100Ib after turning to controversial diabetes jab Ozempic - now better known for its impact on tackling obesity. 

And the results were evident as she visited Paramount Studios ahead of the CBS fall schedule announcement. 

Dressed in a semi-sheer blouse, Bates, 76, looked notably slimmer as she mingled with guests during Wednesday's event. 

With a cinched waist, the actress's black pleated skirt drew further attention to her slender figure - the result of regular dietary jabs and an improved diet.

Bates got serious about her health following her diagnosis for type 2 diabetes in 2017, but there was a moment six years prior that truly sparked her weight-loss journey.

The results of an undeniably effective weight loss journey were evident as Kathy Bates attended a CBS television event in Los Angeles on Wednesday evening 

The Oscar winner was portraying sarcastic criminal defense attorney Harriet 'Harry' Korn in David E. Kelley's legal comedy Harry's Law when she realised her weight was an issue  

At the time, the Oscar winner was portraying sarcastic criminal defense attorney Harriet 'Harry' Korn in David E. Kelley's legal comedy Harry's Law, which aired for two seasons on NBC before being canceled in 2012.

'When I was so heavy in Harry's Law, I had to sit down in between every take, and it was awful,' Kathy recalled to People on Sunday.

'I'm ashamed to have put myself through that, to be honest.'

Bates successfully shed 80lbs off her 5ft3in frame before hopping aboard the trendy Ozempic train and dropping an additional 20lbs, which made 'working a lot easier.'

'But now that I've been able to get really healthy, I can move, I can breathe, I can have fun, I'm not sore,' the Matlock producer-star - who also uses a treadmill - added.

'I get tired and realize I'm like an old lady, but even the kids get tired. But it's been a magnificent experience. I never expected to have this at my age, at the end of my career.'

Bates previously told the outlet last October: 'Physically, I'm capable of doing this show. I don't have to sit down. I can stand up all day long and walk and move and breathe and do so many things that I couldn't before.'

The actress - who survived ovarian cancer and breast cancer - has even seen an improvement in her lymphedema since shedding weight and she no longer has to wear compression sleeves on her arms.

The celebrated actress has now ost more than 100Ib after turning to controversial diabetes jab Ozempic - now better known for its impact on tackling obesity 

Dressed in a semi-sheer blouse, Bates looked notably slimmer as she mingled with guests during Wednesday's event

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In the last few years, more and more people have decided to take the type 2 diabetes drug, which allows them to easily shed weight they openly struggled with for decades but can cause yet-to-be-known long-term effects such as pancreatitis.

Celebrities who have admitted to taking semaglutide drugs include Kelly Clarkson, Whoopi Goldberg, Oprah Winfrey, Elon Musk, Rebel Wilson, Chelsea Handler, Amy Schumer, Sharon Osbourne, Sheryl Underwood, Lauren Manzo, Dolores Catania, and Golnesa 'GG' Gharachedaghi.

But for every celebrity who admits to Ozempic, there are many more who've remained suspiciously silent while slimming including Lizzo, Mindy Kaling, Melissa McCarthy, Khloe Kardashian, Lana Del Rey, Christina Aguilera, and Patricia Arquette.

Obesity expert Dr. Andrew Kraftson said most people taking these medications will hit a plateau around the 18-month mark after starting treatment.

'You could tell someone that they're going to lose 15 percent of their weight, potentially, on Ozempic or Wegovy. 

'But once they get to 15 percent, it is not like they're like, "Oh, now I'm satisfied, great,"' Kraftson told the New York Times in 2023.

In the last few years, more and more people have decided to take the type 2 diabetes drug, which allows them to easily shed weight they openly struggled with for decades but can cause yet-to-be-known long-term effects such as pancreatitis

The truth behind new diet drug craze - Hollywood is hooked on it, and social media is fanning demand for the latest weight-loss 'miracle'

Over the summer I was lucky enough to be invited to a 60th birthday at which the after-dinner entertainment was a private performance by one of the UK's leading male pop stars. More eye-popping than the actual show, though, was how incredible said star looked. He was a mere shadow of his former self, prancing around the stage in a silver catsuit. His secret? Semaglutide, or Ozempic as it is branded, a new diet drug that everybody – but everybody, darling, including one of the world's most famous supermodels – is apparently taking. 

Originally developed to treat type 2 diabetes, it is used off-label (for a purpose other than that for which it was licensed) in both the US and the UK to treat obesity. In research conducted by its billionaire manufacturer, the Danish-based pharmaceutical company Novo Nordisk, patients lost an average of 17 per cent of their overall body weight over 68 weeks. This compares with five to nine per cent for 'oldschool' anti-obesity drugs such as Metformin. 

Only available in the UK on the NHS if you have type 2 diabetes, Ozempic can be obtained through a private doctor, and if you are willing to take it without medical supervision – not recommended by doctors (see panel) – you can get it online through various weight-loss programmes. It is sometimes taken in tablet form but more commonly as an injection. 

Originally developed to treat type 2 diabetes, Semaglutide is used off-label. It has been branded as a new diet drug that everybody is apparently taking

Predictably, Hollywood has been aware of Ozempic for a lot longer than us – Variety magazine recently quipped that the drug deserved its own thank-you speech at the Emmys, as so many stars on the podium had obviously been taking it. Elon Musk raved about its more powerful sister drug, Wegovy, on Twitter; Kim Kardashian, it is hotly rumoured, used semaglutide to lose 16lb in order to fit into Marilyn Monroe's dress for the Met Ball. On TikTok the hashtag #ozempic has had more than 285 million views. 

Thanks to the hype, there has been a surge in demand, causing shortages on both sides of the Atlantic, with a backlash against influencers and celebrities hogging supplies ahead of desperate diabetes sufferers. Predictably, Big Pharma has come up with an alternative – tirzepatide (brand name Mounjaro), manufactured by Eli Lilly – but it has yet to be approved by the US Food & Drug Administration for weight loss. 

Novo Nordisk has issued a statement to say its supplies will be replenished by the end of the year, but it hasn't quelled anxiety. At least two middle-aged male friends of mine who started using it in September are getting themselves in a twist about being caught short before the holidays. As one private London GP remarked to me: 'It's like the H RT panic last spring.' 

So what exactly is this drug? Semaglutide belongs to a class called GLP-1 agonists, which not only regulate blood sugar but, as was discovered about a decade ago, also mimic the gut hormones that regulate our appetites – the ones that tell the brain when we are hungry or full. There are, of course, side effects: acid reflux, nausea, exacerbation of IBS symptoms and fatigue (but much less so than in earlier GLP-1 agonists such as Saxenda), as well as pancreatitis, gallstones and, in very high doses, it has caused thyroid tumours in rats. Meanwhile, when you stop using it the effect wears off immediately and in some cases it won't work at all. 

'I would describe semaglutide as an example of very smart science,' says leading consultant endocrinologist Dr Efthimia Karra from her private practice off London's Harley Street. 'But it is not a panacea for everyone. Around a fifth of users do not respond to it. This is because the human body favours weight gain, thus when you lose weight the body will do anything to revert to its highest BMI. The heavier you are the harder it is to lose weight. If a patient has made no progress in three months, I will take them off it.' 

Banker's wife Laura, a native New Yorker in her mid-50s who had hovered between decades, started using it in January. 'The Paleo diet, 5:2, CBT, NLP, bootcamp, diet delivery services – I've tried them all,' she says from the family home in Hampshire, 'and I've always yo-yoed right back. After my last annual checkup I seriously contemplated giving up. Then my doctor suggested semaglutide.' 

After only a month she noticed her clothes had become looser. From then on, the weight started dropping off. 'The strange thing was, I wasn't eating anything different. I just couldn't physically have seconds any more, and the idea of pudding after a full meal had lost its allure.' Three months on, she is two stone lighter ‒ though occasionally she suffers heartburn if she eats too late at night or drinks alcohol ‒ and when we spoke in autumn, she was looking forward to losing another stone by Christmas. 

'There is a niggling voice that tells me it is both risky and lazy to take a drug to lose weight, and I worry that it will all pile on again if I stop taking it. But if it does, I will seriously consider taking it indefinitely.' 

Private London GP Dr Martin Galy has been prescribing semaglutide for about a year to clients who cannot lose the weight they gained in menopause. He has seen it have a transformational effect, too, on much younger women who suffer polycystic ovary syndrome. 'PCOS sufferers are difficult to treat, and you can imagine how body image plays a very important part when it comes to self-esteem.' 

But according to Tom Sanders, professor of nutrition and dietetics at King's College London, it is not a magic bullet. Commenting on a study on semaglutide published in The New England Journal of Medicine in 2021, he says, 'The challenge post-weight loss is to prevent a regain in weight,' he wrote. It may prove to be useful in the short term, but 'public health measures that encourage behavioural changes such as regular physical activity and moderating dietary energy intake are still needed'. 

That said, given our rising national obesity statistics and the escalation in accompanying health issues such as heart failure, cancer and obstructive sleep apnoea clogging up hospital beds, we're going to need something. Semaglutide may be the rich person's drug today, but might it be approved for more widespread use? Only time will tell.

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Semaglutide injectables can cost $25/month for qualified patients under insurance, but it costs anywhere between $600 and $1,300 for a month supply of four weekly pens out-of-pocket